Adam (Joseph Gordon-Levitt) is diagnosed with cancer and must navigate the road to recovery with assistance from his lad of a best friend Kyle (Seth Rogen) and his therapist Katherine (played by Anna Kendrick), who happens to be new to her role as a therapist, alongside his overbearing mother (Anjelica Huston).

“These are really good.  How strong are they?”

Balancing the world he knows with the world he doesn’t – Adam discovers a kinship in his disease with fellow sufferers, Mitch and Alan (Matt Frewer and Philip Baker Hall) who offer him their own form of therapy.

With a 50% chance of survival and a close circle of friends, old and new, Adam sets out to beat the odds.

“You’re not joking.”

Based on a true story, 50/50 has a superb cast – Gordon-Levitt lights up the screen wherever he goes, Rogen may not be too far away from familiar territory thought breathes life and likeability into Adam’s crude best friend, whilst Kendrick and Huston are wonderful on screen.

Cancer will always be a sensitive subject – it destroys lives, not just for the victim, but for those around them – but 50/50 handles it in a humane, honest and humorous way as we follow Adam on his journey and the highs and the lows.

Will Reiser’s script, based on his own story and encouraged by the support of Seth Rogen, gives us a film described as a comedy.  It certainly has its laugh out loud moments, though is more of a lighthearted drama and is never overly sentimental.

Without a doubt, this is Joseph Gordon-Levitt’s film, once more proving that he’s one of the most talented and versatile actors of his generation.

A powerhouse of a film that deals with its subject in an open way, 50/50 is highly recommended.